http://mathforum.org/~josh/longevity_page/vegan.html l-cysteine from swanson http://www.swansonvitamins.com/NWF324/ItemDetail list of foods https://sites.google.com/site/methionineproject/ list of methionine+cystine to lysine ratio http://nutritiondata.self.com/foods-018990600500000000000-3.html great listing of foods with methionine content http://mathforum.org/~josh/longevity_page/vegan.html All these suggest that lowering of methionine levels is involved in the control of mitochondrial oxidative stress and vertebrate longevity by at least two different mechanisms: decreasing the sensitivity of proteins to oxidative damage, and lowering of the rate of ROS generation at mitochondria. Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection http://www.ncbi.nlm.nih.gov/pubmed/16574059 Summary: there is lots of evidence that methionine restriction lowers oxidative stress, and extends life span in vertibrates Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins http://www.ncbi.nlm.nih.gov/pubmed/16770005 We have found, for the first time, that MetR profoundly decreases mitROS production, decreases oxidative damage to mtDNA, lowers membrane unsaturation, and decreases all five markers of protein oxidation measured in rat heart and liver mitochondria. A Great list of articles on methionine http://www.ncbi.nlm.nih.gov/sites/entrez?itool=pubmed_Abstract&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&IdsFromResult=16770005 Interaction between Dietary Methionine and Methyl Donor Intake on Rat Liver Betaine-homocysteine Methyltransferase Gene Expression and Organization of the Human Gene* http://www.lifexonline.com/luteolin_pdfs_1/Luteolin_Prostate_Cancer_68.pdf summary: Methionone downregulates mrna transcription of mrna from dna supplemental betaine upregulates transcription of mrna from dna However, healthy mammalian cells can convert homocysteine to methionine, cancerious cells generally can not, and will die on a low methionine diet article on cysteine http://www.whfoods.com/genpage.php?tname=nutrient&dbid=54 Cysteine is found in a variety of foods including poultry, yogurt, egg yolks, red peppers, garlic, onions, broccoli, Brussel sprouts, oats, and wheat germ. The NAS lumped cysteine together with another sulfur-containing amino acid, methionine, and recommended that all individuals 1 year of age or greater consume 25 milligrams of cysteine plus methione (combined) for every 1 gram of food protein. Molecular Mechanisms of Cell Cycle Block by Methionine Restriction in Human Prostate Cancer Cells Shan Lu and Daniel E. Epner The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy Mark F. McCarty *, Jorge Barroso-Aranda, Francisco Contreras www.oasisofhope.com/media/pdf/met_vegan.pdf Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691799/ Summary: Median longevity was 948 days in the control group (95% confidence interval 884–1,003 days) compared with 1,011 days (95% confidence interval 931–1,085 days) in the Meth-R group, an increase of 7%. Dexcripts diet fed to people with cancer diet did not hurt them http://69.164.208.4/files/Nutrient%20Intake%20and%20Nutritional%20Indexes%20in% chrome://downloads/home/csims/Downloads/Nutrient%20Intake%20and%20Nutritional%20Indexes%20in%20Adults%20With%20Metastatic%20Cancer%20on%20a%20Phase%20I%20Clinical%20Trial.pdf http://www.ncbi.nlm.nih.gov/pubmed/17050102 The results of this study suggest that betaine can spare methionine in its function as an essential amino acid and is as effective as methionine in improving performance and carcase quality of growing broilers if the diet is moderately deficient in methionine. dieting is too hard to treat cancer, chomo therapy is better http://www.cancertreatmentreviews.com/article/S0305-7372(03)00118-X/abstract http://colleges.ksu.edu.sa/FoodsAndAgriculture/Documents/Research_Papers/28.pdf Pumpkin seed kernels contained moderate concentrations of minerals, especially P, Mg, and K. The amino acid profiles indicate that methionine and tryptophan were the most limiting amino acids, while arginine, glutamic, and aspartic acids were the most plentiful amino acids. We previously showed that rat liver betaine-homocysteine methyltransferase (BHMT) mRNA content and activity increased 4-fold when rats were fed a methionine-deficient diet containing adequate choline, compared with rats fed the same diet with control levels of methionine (Park, E. I., Renduchintala, M. S., and Garrow, T. A. (1997) J. Nutr. Biochem.8, 541–545). http://www.jbc.org/content/274/12/7816.full summary: the rat makes enzymes to convert other methyl donors like homocystein and betaine into methionine review of methionine restriction research http://www.examiner.com/article/advances-aging-research-why-methionine-restriction-is-an-attractive-life-extension-strategy calorie restriction society http://www.crsociety.org/